Difference between revisions of "Mirtazapine-amitriptyline"

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| to = amitriptyline  
 
| to = amitriptyline  
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day.
+
{{TCAdecrease25p3d}}
* '''Day 1:''' reduce a dosage of 30 mg/day to 15 mg/day.
+
| start =  
* '''Day 8:''' stop administration of mirtazapine.
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{{TCAincrease25p3d}}
| start =
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| info =
No wash-out period is needed.
+
{{TCAplasmalevelmonitoring}}
* '''Day 1:''' simultaneously start administration of amitriptyline in a dosage of 50 mg/day.
 
* '''Day 8:''' If necessary, increase dosage of amitriptyline.
 
* Start low, go slow.
 
| info =  
 
{{review}}
 
 
}}
 
}}

Latest revision as of 13:02, 30 June 2023

Mirtazapine
Type Antidepressant
Group other
links
Medscape Mirtazapine
PubChem 4205
PubMed Mirtazapine
Kompas (Dutch) Mirtazapine
Wikipedia Mirtazapine
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from mirtazapine to amitriptyline.[1] [2]

Nietinrijdenbord.png Stop mirtazapine
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start amitriptyline
  • Day 1: Increase with about 25% of target dose per 3 days.
Infobord.png More information
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. (dutch) monografie.org tricyclische-antidepressiva
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