Difference between revisions of "Amitriptyline-trazodone"

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| to = trazodone  
 
| to = trazodone  
 
| stop =  
 
| stop =  
{{stopAmitriptyline}}
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{{TCAdecrease25p3d}}
| start =  
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| start = {{StartAntidepressant}}
No wash-out period is needed.
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| info =
* '''Day 4:''' simultaneously start administration of trazodone in a dosage of 150 mg/day.
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* Safe target dose trazodone = 150 mg
* '''Day 15:''' continue only administration of trazodone. If necessary, increase the dosage of trazodone to a maximum of 400 mg/day.
 
| info =
 
* {{theorSS}}
 
 
}}
 
}}

Latest revision as of 10:57, 30 June 2023

Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline
Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone

Switch medication from amitriptyline to trazodone.[1] [2]

Nietinrijdenbord.png Stop amitriptyline
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start trazodone
  • Day 1: Start with 50% of the target dose
  • Day 8: Increase dose to 100% of the target dose
  • Day 9 and after: Gradually increase dose as necessary
Infobord.png More information
  • Safe target dose trazodone = 150 mg
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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