Difference between revisions of "Doxepine-hypericum"

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| to = hypericum  
 
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* '''Before day 0:''' gradually reduce dosage of doxepin to a maximum of 100 mg/day, when this dosage is > 100 mg/day.
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{{stopDoxepin}}
* '''Day 1:''' reduce dosage of doxepin to 50 mg/day.
 
* '''Day 8:''' reduce dosage of doxepin to 25 mg/day.
 
* '''Day 15:''' stop administration of doxepin.
 
 
| start =  
 
| start =  
* '''Day 15-22:''' a wash-out period of one week is necessary.
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* '''Day 15-22:''' a wash-out period is necessary.
* '''Day 23:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).
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* '''Day 23:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).<ref>{{Pubmed|18294328|Imai H, Kotegawa T, Tsutsumi K, Morimoto T, Eshima N, Nakano S, Ohashi K. The recovery time-course of CYP3A after induction by St John's wort administration.  Br J Clin Pharmacol. 2008 May;65(5):701-7.}}</ref><ref>{{Pubmed|16640452|Wurglics M, Schubert-Zsilavecz M. Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.}}</ref><ref>{{Pubmed|19593191|Derijks HJ, Janknegt R, Heerdink ER, De Koning FH, Krekels MM, Looij BJ, Egberts AC. Influence of antidepressant use on glycemic control in patients with diabetes mellitus: an open-label comparative study. J Clin Psychopharmacol. 2009 Aug;29(4):405-8.}}</ref><ref name="informatorium">{{KNMP|doxepine}}</ref>
| info =
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
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| caveat =
* Hypericum slows the metabolism of doxepin via CYP3A4. }}
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{{caveSS}}
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| info =
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{{HypericumInfo}}
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Latest revision as of 16:14, 28 October 2015

Doxepin
Type antidepressant
Group TCA
links
ATC-code N06AA12
Medscape Doxepin
PubChem 3158
PubMed Doxepin
Drugs.com doxepin
Kompas (Dutch) Doxepin
Wikipedia Doxepin
Hypericum
Type Antidepressant
Group other
links
EMEA 10130408en
PubMed Hypericum
Kompas (Dutch) hypericum extract
Wikipedia St John's wort

Switch medication from doxepin to hypericum.[2] [3]

Nietinrijdenbord.png Stop doxepin
  • Before day 1: gradually reduce dosage of doxepin to a maximum of 100 mg/day, when this dosage is > 100 mg/day.
  • Day 1: reduce dosage of doxepin to 50 mg/day.
  • Day 8: reduce dosage of doxepin to 25 mg/day.
  • Day 15: stop administration of doxepin.
Eenrichtingbord.png Start hypericum
  • Day 15-22: a wash-out period is necessary.
  • Day 23: start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).[4][5][6][1]
Letopbord.png Cave
Infobord.png More information
  • Hypericum induces enzymes of the CYP P-450 type and P-gp type.
  • Hypericum might have MAO-inhibiting and/or COMT-inhibiting properties.
  • Many studies reported that hypericin is the main source of pharmacological effects of hypericum. However the IC50 of hypericin to inhibit MAO A and MAO B is 100- to 1000-fold higher than accessible Cmax values of hypericin after oral administration of hypericum.[7]
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