Difference between revisions of "Hypericum-mirtazapine"

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(Created page with '{{ Drugswitch | from = hypericum | to = mirtazapine | stop = * Administration of hypericum can be stopped abruptly. | start = * '''Day 1-7:''' a wash-out period of one week ...')
 
 
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| to = mirtazapine  
 
| to = mirtazapine  
 
| stop =  
 
| stop =  
* Administration of hypericum can be stopped abruptly.
+
* '''Day 1-14:'''Gradually decrease the dosage of hypericum.
| start =  
+
* '''Day 15:''' stop administration of hypericum.
* '''Day 1-7:''' a wash-out period of one week is necessary.
+
| start =
* '''Day 8:''' start administration of mirtazapine in a dosage of 15 mg/day.
+
* '''Day 15-22:''' a wash-out period of one week is necessary.
* '''Day 15:''' increase dosage of mirtazapine to 30 mg/day.
+
* '''Day 23:''' start administration of mirtazapine in a dosage of 15 mg/day.
 +
* '''Day 30:''' increase dosage of mirtazapine to 30 mg/day.
 
* If necessary, increase dosage of mirtazapine further.
 
* If necessary, increase dosage of mirtazapine further.
 
| info =  
 
| info =  
* Occurence of the serotonin syndrome is theoretically possible.
+
{{nointeractions}}
* Hypericum slows the metabolism of citalopram/escitalopram via CYP3A4. This effect may persist up to two weeks after stopping hypericum, so caution is necessary.}}
+
}}

Latest revision as of 13:15, 7 October 2015

Hypericum
Type Antidepressant
Group other
links
EMEA 10130408en
PubMed Hypericum
Kompas (Dutch) hypericum extract
Wikipedia St John's wort
Mirtazapine
Type Antidepressant
Group other
links
Medscape Mirtazapine
PubChem 4205
PubMed Mirtazapine
Kompas (Dutch) Mirtazapine
Wikipedia Mirtazapine

Switch medication from hypericum to mirtazapine.[1] [2]

Nietinrijdenbord.png Stop hypericum
  • Day 1-14:Gradually decrease the dosage of hypericum.
  • Day 15: stop administration of hypericum.
Eenrichtingbord.png Start mirtazapine
  • Day 15-22: a wash-out period of one week is necessary.
  • Day 23: start administration of mirtazapine in a dosage of 15 mg/day.
  • Day 30: increase dosage of mirtazapine to 30 mg/day.
  • If necessary, increase dosage of mirtazapine further.
Infobord.png More information
  • No severe interactions are known.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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