Difference between revisions of "Venlafaxine-clomipramine"

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* '''Day 15:''' start administration of clomipramine in a low dosage of 25 mg/day.
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* “Start low, go slow” for clomipramine, and caution with this switch is necessary.
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Latest revision as of 13:21, 30 June 2023

Venlafaxine
Type Antidepressant
Group SNRI
links
Medscape Venlafaxine
PubChem 5656
PubMed Venlafaxine
Kompas (Dutch) Venlafaxine
Wikipedia Venlafaxine
Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine

Switch medication from venlafaxine to clomipramine.[1] [2]

Nietinrijdenbord.png Stop venlafaxine
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start clomipramine
  • Day 1: Increase with about 25% of target dose per 3 days.
Infobord.png More information
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. (dutch) monografie.org tricyclische-antidepressiva
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