Difference between revisions of "Paroxetine-duloxetine"
From Psychiatrienet
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| from = paroxetine | | from = paroxetine | ||
| to = duloxetine | | to = duloxetine | ||
| − | | stop = | + | | stop = {{StopSSRI,SNRI}} |
| − | + | | start = {{StartAntidepressant}} | |
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| − | | start = | ||
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| info = | | info = | ||
| − | {{theorSS}} | + | * Safe target dose duloxetine = 60 mg |
| + | * {{theorSS}} | ||
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Latest revision as of 16:40, 24 February 2023
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Switch medication from paroxetine to duloxetine.[1] [2]
Stop paroxetine - Day 1: Decrease dose to 50%
- Day 8: Stop
Start duloxetine- Day 1: Start with 50% of the target dose
- Day 8: Increase dose to 100% of the target dose
- Day 9 and after: Gradually increase dose as necessary
More information- Safe target dose duloxetine = 60 mg
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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