Difference between revisions of "Fluoxetine-tranylcypromine"
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| − | * | + | * Stop and wait five weeks for washout. |
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| − | + | * a wash-out period of five weeks is necessary because of the long half live. | |
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| + | * Desmethylfluoxetine has a half live of about one week so a long wash-out period is necessary. | ||
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Latest revision as of 12:32, 8 March 2024
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Switch medication from fluoxetine to tranylcypromine.[1] [2]
Stop fluoxetine - Before day 1: reduce dosage of fluoxetine with about 20 mg per week.
- Day 1: when a dosage of 20 mg/day is reached, stop fluoxetine.
- Stop and wait five weeks for washout.
Start tranylcypromine- a wash-out period of five weeks is necessary because of the long half live.
- Start tranylcypromine in a low dosage of 20 mg/day for one week.
- After this week the dosage of tranylcypromine can be increased.
Cave- Occurrence of the serotonin syndrome is possible without wash-out period.
More information- Desmethylfluoxetine has a half live of about one week so a long wash-out period is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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