Difference between revisions of "Aripiprazole-Haloperidol"
From Psychiatrienet
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| from = Aripiprazole | | from = Aripiprazole | ||
| to = Haloperidol | | to = Haloperidol | ||
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| + | * '''Day 1-21:''' {{Cont}} | ||
| + | * '''Day 22:''' {{Stop}} | ||
| start = {{StartStand}} | | start = {{StartStand}} | ||
| + | * '''Day 28:''' Reevaluate dose, if necessary adjust dose | ||
| + | | view = StopAbruptly21StartGradually2.jpg | ||
| info = {{caveQT}} | | info = {{caveQT}} | ||
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Latest revision as of 08:48, 12 August 2009
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Switch medication from Aripiprazole to Haloperidol.[5] [6]
Stop Aripiprazole - Day 1-21: Continue drug at usual dose
- Day 22: Stop drug
Start Haloperidol- Day 1-4: approx. 25% of target dose
- Day 5-8: approx. 50% of target dose
- Day 9-12: approx. 75% of target dose
- Day 13: target dose
- Day 28: Reevaluate dose, if necessary adjust dose
More information- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[7]
— Aripiprazole — Haloperidol
- ↑ WHO Collaborating Centre for Drug Statistics Methodology ATC=N05AD01
- ↑ 2.0 2.1 2.2 KNMP; Informatorium Medicamentorum 2023; Monografie "haloperidol" (Dutch)
- ↑ 3.0 3.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- ↑ 4.0 4.1 Farmacotherapeutisch Kompas; Inleidende Tekst Antipsychotica (dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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