Difference between revisions of "Template:HypericumInfo"
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* Hypericum induces enzymes of the [[wp:Cytochrome P450 reductase|CYP P-450]] type and P-gp type. | * Hypericum induces enzymes of the [[wp:Cytochrome P450 reductase|CYP P-450]] type and P-gp type. | ||
| − | * Hypericum might have [[wp:Monoamine oxidase inhibitor|MAO-inhibiting]] and/or [[wp:COMT inhibitor|COMT-inhibiting]] properties. | + | * Hypericum might have [[wp:Monoamine oxidase inhibitor|MAO-inhibiting]] and/or [[wp:COMT inhibitor|COMT-inhibiting]] properties. |
| + | * Many studies reported that hypericin is the main source of pharmacological effects of hypericum. However the IC50 of hypericin to inhibit MAO A and MAO B is 100- to 1000-fold higher than accessible Cmax values of hypericin after oral administration of hypericum.<ref name ="Wurglics2006">{{Pubmed|16640452|Wurglics M, Schubert-Zsilavecz M.Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.}}</ref> | ||
Latest revision as of 14:11, 4 August 2023
- Hypericum induces enzymes of the CYP P-450 type and P-gp type.
- Hypericum might have MAO-inhibiting and/or COMT-inhibiting properties.
- Many studies reported that hypericin is the main source of pharmacological effects of hypericum. However the IC50 of hypericin to inhibit MAO A and MAO B is 100- to 1000-fold higher than accessible Cmax values of hypericin after oral administration of hypericum.[1]
