Difference between revisions of "Zuclopenthixol MA-Paliperidone LA"
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{{Drugswitch | {{Drugswitch | ||
| from = Zuclopenthixol_MA | | from = Zuclopenthixol_MA | ||
| to = Paliperidone_LA | | to = Paliperidone_LA | ||
| stop = {{lastinjection}} | | stop = {{lastinjection}} | ||
| − | | start = {{ | + | | start = {{StartDepot}} |
| − | + | | info = {{caveQT}}{{Zuclopenthixol_MA}} | |
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Latest revision as of 15:08, 28 January 2013
There are 2 switch possibities:
Number 1 (the general approach):
- Day 1: Switch to oral risperidone (or oral paliperidone): see this switch in the main cross table.
- Day 1-29: Maintain on oral risperidone (or oral paliperidone) and examine the effects.
- Day 30: stop oral risperidone (or oral paliperidone) and administer paliperidone-LA: see this switch in the main cross table.
Oral risperidone has better and more stable bioavailability properties than has oral 9-OH-risperidone=paliperidone. Food increases the absorption with 50-60% of the latter.
Number 2 (if a patient in the past reacted well on risperidon or paliperidone=9-OH-risperidone):
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Switch medication from Zuclopenthixol_MA to Paliperidone_LA.[1] [2]
Stop Zuclopenthixol_MA - Day 1: Last depot injection
Start Paliperidone_LA- Day 1: Start depot according general dosing advice (Dotted line in graph)
More information- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[3]
- Zuclopenthixol_MA = Zuclopenthixol acetate [4]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
- ↑ SPC Zuclopenthixol acetate
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