Difference between revisions of "Imipramine-amitriptyline"
From Psychiatrienet
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| − | {{Drugswitch | + | {{Drugswitch |
| − | | from = imipramine | + | | from = imipramine |
| − | | to = amitriptyline | + | | to = amitriptyline |
| stop = | | stop = | ||
| − | + | {{TCAdecrease25p3d}} | |
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| start = | | start = | ||
* No wash-out period is needed. | * No wash-out period is needed. | ||
| − | + | {{TCAincrease25p3d}} | |
| info = | | info = | ||
* {{TCAantichol}} | * {{TCAantichol}} | ||
| + | {{TCAplasmalevelmonitoring}} | ||
}} | }} | ||
Latest revision as of 11:31, 30 June 2023
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Switch medication from imipramine to amitriptyline.[1] [2]
Stop imipramine - Day 1: Decrease with about 25% of the original dose per 3 days.
Start amitriptyline- No wash-out period is needed.
- Day 1: Increase with about 25% of target dose per 3 days.
More information- Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
- Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ (dutch) monografie.org tricyclische-antidepressiva
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