Difference between revisions of "Bupropion-dosulepine"
From Psychiatrienet
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| to = dosulepine | | to = dosulepine | ||
| stop = | | stop = | ||
| − | + | {{StopBupropion}} | |
| − | + | | start = | |
| − | | start = | + | * '''Day 1:''' start administration of dosulepine in a low dosage of 25 mg/day. |
| − | * '''Day 1 | + | * '''Day 8:''' increase dosage of dosulepine to a dosage of 75 mg/day. |
| − | * '''Day | ||
| info = | | info = | ||
* Bupropion slows the metabolism of dosulepine via CYP2D6. | * Bupropion slows the metabolism of dosulepine via CYP2D6. | ||
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* {{RiskSeizureBupropionTCA}} | * {{RiskSeizureBupropionTCA}} | ||
| + | * {{TCAplasmalevelmonitoring}} | ||
}} | }} | ||
Latest revision as of 10:59, 4 August 2023
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Switch medication from bupropion to dosulepine.[1] [2]
Stop bupropion - Day 1: Stop bupropion.
- bupropion can be stopped abruptly for every dosage.[3]
Start dosulepine- Day 1: start administration of dosulepine in a low dosage of 25 mg/day.
- Day 8: increase dosage of dosulepine to a dosage of 75 mg/day.
More information- Bupropion slows the metabolism of dosulepine via CYP2D6.
- The concomitant use of bupropion and tricyclic antidepressants (TCAs) may potentiate the risk of seizures. These agents are all epileptogenic and may have additive effects on the seizure threshold.
- Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[4]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Multidisciplinair document Afbouwen Overige Antidepressiva 2023
- ↑ (dutch) monografie.org tricyclische-antidepressiva
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