Difference between revisions of "Template:CombiCaLa"
From Psychiatrienet
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| − | * Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. <ref name="Koch"> {{Pubmed|12648898|Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by carbamazepine. J Clin Psychiatry 2005;66:400-1}}</ref> | + | * Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase.<ref name="Koch"> {{Pubmed|12648898|Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by carbamazepine. J Clin Psychiatry 2005;66:400-1}}</ref> |
* Carbamazepine likely speeds the metabolism of lamotrigine, but the clinical significance is unclear.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref><ref name="levyrh"> Levy RH et al, Metabolic Drug Interactions, Lippincott Williams & Wilkins, Philadelphia, 2000.</ref> | * Carbamazepine likely speeds the metabolism of lamotrigine, but the clinical significance is unclear.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref><ref name="levyrh"> Levy RH et al, Metabolic Drug Interactions, Lippincott Williams & Wilkins, Philadelphia, 2000.</ref> | ||
| − | * Lamotrigine may increase blood levels of carbamazepine metabolites, which can result in neurotoxicity (data about this are contradictory). <ref name="freeman" /><ref name="levyrh" /> | + | * Lamotrigine may increase blood levels of carbamazepine metabolites, which can result in neurotoxicity (data about this are contradictory).<ref name="freeman" /><ref name="levyrh" /> |
| − | * These two agents have less significant pharmacologic interactions than do lamotrigine and valproate <ref name="freeman"/><ref name="levyrh"> Levy RH et al, Metabolic Drug Interactions, Lippincott Williams & Wilkins, Philadelphia, 2000.</ref> | + | * These two agents have less significant pharmacologic interactions than do lamotrigine and valproate.<ref name="freeman"/><ref name="levyrh"> Levy RH et al, Metabolic Drug Interactions, Lippincott Williams & Wilkins, Philadelphia, 2000.</ref> |
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Latest revision as of 15:33, 23 April 2010
- Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase.[1]
- Carbamazepine likely speeds the metabolism of lamotrigine, but the clinical significance is unclear.[2][3]
- Lamotrigine may increase blood levels of carbamazepine metabolites, which can result in neurotoxicity (data about this are contradictory).[2][3]
- These two agents have less significant pharmacologic interactions than do lamotrigine and valproate.[2][3]
- ↑ Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by carbamazepine. J Clin Psychiatry 2005;66:400-1
- ↑ 2.0 2.1 2.2 Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
- ↑ 3.0 3.1 3.2 Levy RH et al, Metabolic Drug Interactions, Lippincott Williams & Wilkins, Philadelphia, 2000.
