Difference between revisions of "Fluoxetine-vortioxetine"
From Psychiatrienet
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| to = vortioxetine | | to = vortioxetine | ||
| stop = | | stop = | ||
| − | * '''Before day 1:''' | + | * '''Before day 1:''' reduce dosage of fluoxetine to 20 mg/day, when this dosage is > 20 mg/day. |
| − | * '''Day 1:''' | + | * '''Day 1:''' stop administration |
| start = | | start = | ||
| − | * A wash-out period | + | * '''Day 1-21:''' A wash-out period is needed. |
| − | * '''Day | + | * '''Day 22:''' Start vortioxetine in a dosage of 10 mg/day. |
| − | | info = | + | * '''After day 28 :''' If necessary, increase gradually the dosage of vortioxetine. |
| − | * Fluoxetine | + | | info = |
| − | + | * Fluoxetine slows the metabolism of vortioxetine via CYP2D6, so caution is necessary for at least four weeks after stopping fluoxetine. | |
| + | * {{theorSS}} | ||
| + | {{review}} | ||
}} | }} | ||
Latest revision as of 15:20, 21 October 2015
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Switch medication from fluoxetine to vortioxetine.[1] [2]
Stop fluoxetine - Before day 1: reduce dosage of fluoxetine to 20 mg/day, when this dosage is > 20 mg/day.
- Day 1: stop administration
Start vortioxetine- Day 1-21: A wash-out period is needed.
- Day 22: Start vortioxetine in a dosage of 10 mg/day.
- After day 28 : If necessary, increase gradually the dosage of vortioxetine.
More information- Fluoxetine slows the metabolism of vortioxetine via CYP2D6, so caution is necessary for at least four weeks after stopping fluoxetine.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- This switch is currently being reviewed.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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