Difference between revisions of "Paroxetine-vortioxetine"
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| − | * | + | * '''Day 15-18:''' a wash-out period of 3 days is to prevent inhibition of the metabolism of vortioxetine. |
| − | * '''Day | + | * '''Day 18:''' start administration of vortioxetine in a normal dosage of 10 mg/day. |
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* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. | * Paroxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. | ||
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | ||
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Latest revision as of 14:44, 12 March 2015
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Switch medication from paroxetine to vortioxetine.[1] [2]
Stop paroxetine - Day -7: reduce dosage of paroxetine to 20 mg/day, if this dosage is > 20 mg/day.
- Day 0: dosage of paroxetine is 20 mg/day.
- Day 1: reduce dosage of paroxetine to 10 mg/day.
- Day 8: reduce dosage of paroxetine to 5 mg/day.
- Day 15: stop administration of paroxetine.
Start vortioxetine- Day 15-18: a wash-out period of 3 days is to prevent inhibition of the metabolism of vortioxetine.
- Day 18: start administration of vortioxetine in a normal dosage of 10 mg/day.
More information- Paroxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine.
- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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