Difference between revisions of "Duloxetine-nortriptyline"

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| to = nortriptyline
 
| to = nortriptyline
 
| stop =  
 
| stop =  
* '''Before day 0:''' gradually reduce dosage of bupropion to a maximum of 60 mg/day.
+
{{TCAdecrease25p3d}}
* '''Day 1:''' reduce the dosage of duloxetine to 30 mg/day.
 
 
| start =  
 
| start =  
No wash-out period is needed.
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{{TCAincrease25p3d}}
* '''Day 1:''' simultaneously start administration of nortriptyline in a low dosage of 25 mg/day.
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| info =
* '''Day 8:''' stop administration of duloxetine and increase the dosage of nortriptyline to 50 mg/day.
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{{TCAplasmalevelmonitoring}}
| info =
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}}
* Duloxetine slows the metabolism of nortriptyline by CYP2D6.
 
* Caution is necessary at the start of administration of nortriptyline. }}
 

Latest revision as of 12:52, 30 June 2023

Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine
Nortriptyline
Type Antidepressant
Group TCA
links
Medscape Nortriptyline
PubChem 4543
PubMed Nortriptyline
Kompas (Dutch) Nortriptyline
Wikipedia Nortriptyline

Switch medication from duloxetine to nortriptyline.[1] [2]

Nietinrijdenbord.png Stop duloxetine
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start nortriptyline
  • Day 1: Increase with about 25% of target dose per 3 days.
Infobord.png More information
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. (dutch) monografie.org tricyclische-antidepressiva
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