Difference between revisions of "Tranylcypromine-vortioxetine"
From Psychiatrienet
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Latest revision as of 11:19, 28 October 2015
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Switch medication from tranylcypromine to vortioxetine.[1] [2]
Stop tranylcypromine - Day 1: decrease the original dose with about 25% every 3 days.
- Day 9: stop administration of tranylcypromine.
Start vortioxetine- A wash-out period of two weeks is necessary.
- Day 28: start administration of vortioxetine in a normal dosage of 10 mg/day. [3]
Cave- Occurrence of the serotonin syndrome is possible without a wash-out period.
More information- After the last dose of tranylcypromine it takes about 14 days to restore the activity of the MAO enzymes
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ KNMP; Informatorium Medicamentorum 2023; Monografie "tranylcypromine" (Dutch)
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