Difference between revisions of "Venlafaxine-maprotiline"

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(Created page with '{{Drugswitch | from = venlafaxine | to = maprotiline | stop = * '''Day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day. * '''Day 1:''' reduce a dosage o...')
 
 
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| to = maprotiline
 
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* '''Day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.
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{{TCAdecrease25p3d}}
* '''Day 1:''' reduce a dosage of 75 mg/day to 37,5 mg/day.
 
 
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| start =  
* '''Day 1:''' simultaneously start administration of maprotiline in a low dosage of 25-75 mg/day.
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{{TCAincrease25p3d}}
* '''Day 8:''' stop administration of venlafaxine and continue administration of maprotiline.
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| info =
| info =
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{{TCAplasmalevelmonitoring}}
* “Start low, go slow” is not required, but caution with this switch is necessary.
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}}
* Venlafaxine is a weak inhibitor of CYP2D6, which metabolizes maprotiline.}}
 

Latest revision as of 13:22, 30 June 2023

Venlafaxine
Type Antidepressant
Group SNRI
links
Medscape Venlafaxine
PubChem 5656
PubMed Venlafaxine
Kompas (Dutch) Venlafaxine
Wikipedia Venlafaxine
Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline

Switch medication from venlafaxine to maprotiline.[1] [2]

Nietinrijdenbord.png Stop venlafaxine
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start maprotiline
  • Day 1: Increase with about 25% of target dose per 3 days.
Infobord.png More information
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. (dutch) monografie.org tricyclische-antidepressiva
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