Difference between revisions of "Bupropion-venlafaxine"

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* '''Day 1-7:''' a wash-out period of at least one week is necessary.  
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* ''' Day 1: ''' Start venlafaxine with a dosage of 37,5 mg/day.
* '''Day 8:''' start venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day. Increase the dose with about 25% of the target dose every 3 days
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* ''' Day 8: ''' increase dosage of venlafaxine to a dosage of 75 mg/day.
 
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* By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur.
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* Bupropion slows the metabolism of venlafaxine by CYP2D6.
* Bupropion slows the metabolism of venlafaxine by CYP2D6.<ref> Kennedy et al, [http://www.ncbi.nlm.nih.gov/pubmed/11926715?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum Combining bupropion SR with venlafaxine, paroxetine, or fluoxetine: a preliminary report on pharmacokinetic, therapeutic, and sexual dysfunction effects.]. J Clin Psychiatry 2002 March;63(3):181-6.</ref>
 
 
 
 
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Latest revision as of 11:45, 4 August 2023

Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion
Venlafaxine
Type Antidepressant
Group SNRI
links
Medscape Venlafaxine
PubChem 5656
PubMed Venlafaxine
Kompas (Dutch) Venlafaxine
Wikipedia Venlafaxine

Switch medication from bupropion to venlafaxine.[1] [2]

Nietinrijdenbord.png Stop bupropion
  • Day 1: Stop bupropion.
  • bupropion can be stopped abruptly for every dosage.[3]
Eenrichtingbord.png Start venlafaxine
  • Day 1: Start venlafaxine with a dosage of 37,5 mg/day.
  • Day 8: increase dosage of venlafaxine to a dosage of 75 mg/day.
Infobord.png More information
  • Bupropion slows the metabolism of venlafaxine by CYP2D6.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Multidisciplinair document Afbouwen Overige Antidepressiva 2023
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