Difference between revisions of "Sertraline-mirtazapine"

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| from = sertraline  
 
| from = sertraline  
 
| to = mirtazapine  
 
| to = mirtazapine  
| stop =  
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| stop = {{StopSSRI,SNRI}}
* Gradually reduce dosage of sertraline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
+
| start = {{StartAntidepressant}}
| start =
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| info =
* '''Day 1:''' reduce sertraline to a dosage of 25 mg/day and start administration of mirtazapine in a normal dosage of 15-30 mg/day for one week.
+
* Safe target dose mirtazapine = 15 mg
* '''Day 8:''' stop administration of sertraline and continue administration of just mirtazapine.
 
|info=
 
{{review}}
 
 
 
 
}}
 
}}

Latest revision as of 16:56, 24 February 2023

Sertraline
Type Antidepressant
Group SSRI
links
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline
Mirtazapine
Type Antidepressant
Group other
links
Medscape Mirtazapine
PubChem 4205
PubMed Mirtazapine
Kompas (Dutch) Mirtazapine
Wikipedia Mirtazapine

Switch medication from sertraline to mirtazapine.[1] [2]

Nietinrijdenbord.png Stop sertraline
  • Day 1: Decrease dose to 50%
  • Day 8: Stop
Eenrichtingbord.png Start mirtazapine
  • Day 1: Start with 50% of the target dose
  • Day 8: Increase dose to 100% of the target dose
  • Day 9 and after: Gradually increase dose as necessary
Infobord.png More information
  • Safe target dose mirtazapine = 15 mg
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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