Difference between revisions of "Doxepine-fluvoxamine"
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Latest revision as of 13:26, 2 November 2015
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Switch medication from doxepin to fluvoxamine.[2] [3]
Stop doxepin - Before day 1: gradually reduce dosage of doxepin to a maximum of 100 mg/day.
- Day 1: reduce dosage of doxepin to 50 mg/day.
- Day 3: reduce dosage of doxepin to 25 mg/day.
- Day 8: stop administration of doxepin.
Start fluvoxamine- Day 3: simultaneously start administration of fluvoxamine in a normal dosage of 50 mg/day.
- Day 8: stop administration of doxepin and continue administration of fluvoxamine in a dosage of 50-100 mg/day.
More information- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary..
- Fluvoxamine is an inhibitor of CYP1A2, CYP2C19 and CYP3A4 (moderate), which metabolize doxepin.
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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