Difference between revisions of "Escitalopram-amitriptyline"

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| to = amitriptyline
 
| to = amitriptyline
 
| stop =  
 
| stop =  
{{stopEscitalopram}}
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{{TCAdecrease25p3d}}
 
 
* '''Before day 1:''' gradually reduce dosage of escitalopram to a maximum of 10 mg/day, when this dosage is  > 10 mg/day.
 
* '''Day 1:''' reduce dosage of escitalopram to a maximum of 5 mg/day.
 
* '''Day 8:''' stop administration of escitalopram.
 
 
 
 
| start =  
 
| start =  
* '''Day 9:''' no wash-out period is needed. Start administration of amitriptyline in a low dosage of 25-50 mg/day.
+
{{TCAincrease25p3d}}
* Start low, go slow!
 
 
| info =
 
| info =
* {{theorSS}}
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{{TCAplasmalevelmonitoring}}
 
}}
 
}}

Latest revision as of 12:54, 30 June 2023

Escitalopram
Type Antidepressant
Group SSRI
links
Medscape Escitalopram
PubChem 10832572
PubMed Escitalopram
Kompas (Dutch) Escitalopram
Wikipedia Escitalopram
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from escitalopram to amitriptyline.[1] [2]

Nietinrijdenbord.png Stop escitalopram
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start amitriptyline
  • Day 1: Increase with about 25% of target dose per 3 days.
Infobord.png More information
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. (dutch) monografie.org tricyclische-antidepressiva
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