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* When a dosage of 10 mg/day is reached, stop administration.
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* '''Day 1-142:''' a wash-out period of two weeks days is necessary. <ref>{{Pubmed|18294328|Imai H, Kotegawa T, Tsutsumi K, Morimoto T, Eshima N, Nakano S, Ohashi K. The recovery time-course of CYP3A after induction by St John's wort administration. Br J Clin Pharmacol. 2008 May;65(5):701-7.}}</ref><ref>{{Pubmed|16640452|Wurglics M, Schubert-Zsilavecz M. Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.}}</ref><ref name="informatorium">{{KNMP|tranylcypromine}}</ref> * '''Day 153:''' start hypericum after this period in a dosage of 300 mg three times a day (900 mg/day).
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* Occurrence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}
