Difference between revisions of "Venlafaxine-hypericum"

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(Created page with '{{ Drugswitch | from = venlafaxine | to = hypericum | stop = * '''Before day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/day, when this dosage is > 75 ...')
 
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| to = hypericum  
 
| to = hypericum  
 
| stop =  
 
| stop =  
* '''Before day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/day, when this dosage is > 75 mg/day.
+
{{downVenla}}
* '''Day 1:''' reduce dosage of venlafaxine to 37,5 mg/day.
 
* '''Day 8:''' stop administration of venlafaxine.
 
 
| start =  
 
| start =  
* '''Day 8-14:''' a wash-out period of one week is necessary.
+
* '''Day 14-21:''' a wash-out period of one week is necessary.
* '''Day 15:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).
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* '''Day 22:''' start administration of hypericum.
 
| info =  
 
| info =  
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
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* Hypericum slows the metabolism of venlafaxine via CYP3A4. }}
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 +
}}

Revision as of 16:11, 17 July 2009

Venlafaxine
Type Antidepressant
Group SNRI
links
Medscape Venlafaxine
PubChem 5656
PubMed Venlafaxine
Kompas (Dutch) Venlafaxine
Wikipedia Venlafaxine
Hypericum
Type Antidepressant
Group other
links
EMEA 10130408en
PubMed Hypericum
Kompas (Dutch) hypericum extract
Wikipedia St John's wort

Switch medication from venlafaxine to hypericum.[1] [2]

Nietinrijdenbord.png Stop venlafaxine
  • Day 1-14: gradually reduce dosage of venlafaxine to a maximum of 37,5 mg or 75 mg (slow release)/ day.
  • Day 15: stop administration of venlafaxine
Eenrichtingbord.png Start hypericum
  • Day 14-21: a wash-out period of one week is necessary.
  • Day 22: start administration of hypericum.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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