Difference between revisions of "Fluoxetine-moclobemide"
From Psychiatrienet
| Line 1: | Line 1: | ||
| − | {{ | + | {{Drugswitch |
| − | | | + | | from = fluoxetine |
| − | | | + | | to = moclobemide |
| − | | | + | | stop = |
| − | | | + | * Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day. |
| − | * | + | * When a dosage of 20 mg/day is reached, stop administration. |
| − | + | | start = | |
| − | }} | + | * '''Day 1-28:''' a wash-out period of four weeks is necessary. |
| + | * '''Day 29:''' start moclobemide the next day in a normal dosage of 300 mg/day. | ||
| + | | info = | ||
| + | * A switch from fluoxetine to moclobemide is not obvious, given the necessary prolonged wash-out period in this case. | ||
| + | * Occurrence of serotonin syndrome is reported when a wash-out period (of four weeks) is not considered.}} | ||
Revision as of 19:45, 3 May 2009
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Switch medication from fluoxetine to moclobemide.[1] [2]
Stop fluoxetine - Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
- When a dosage of 20 mg/day is reached, stop administration.
Start moclobemide- Day 1-28: a wash-out period of four weeks is necessary.
- Day 29: start moclobemide the next day in a normal dosage of 300 mg/day.
More information- A switch from fluoxetine to moclobemide is not obvious, given the necessary prolonged wash-out period in this case.
- Occurrence of serotonin syndrome is reported when a wash-out period (of four weeks) is not considered.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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