Difference between revisions of "Trazodone-agomelatine"
From Psychiatrienet
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* '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day. | * '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day. | ||
| − | * '''Day 8:''' only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day. }} | + | * '''Day 8:''' only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day. |
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| + | * The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given. }} | ||
Revision as of 12:09, 10 July 2009
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Switch medication from trazodone to agomelatine.[1] [2]
Stop trazodone - Before day 0: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
- Day 1: reduce dosage of trazodone to 75-100 mg/day.
- Day 8: stop administration of trazodone.
Start agomelatine- Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.
- Day 8: only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.
More information- The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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