Difference between revisions of "Citalopram-doxepine"
From Psychiatrienet
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| − | {{ | + | {{Drugswitch |
| − | | | + | | from = citalopram |
| − | | | + | | to = doxepin |
| − | | | + | | stop = |
* '''Day 0:''' gradually reduce dosage of citalopram/escitalopram to a maximum of 20 mg/ day resp. 10 mg/day, when this dosage is respectively > 20 mg/day and > 10 mg/day. | * '''Day 0:''' gradually reduce dosage of citalopram/escitalopram to a maximum of 20 mg/ day resp. 10 mg/day, when this dosage is respectively > 20 mg/day and > 10 mg/day. | ||
* '''Day 1:''' reduce dosage of citalopram/escitalopram to a maximum of 10 mg/ day resp. 5 mg/day. | * '''Day 1:''' reduce dosage of citalopram/escitalopram to a maximum of 10 mg/ day resp. 5 mg/day. | ||
| − | | | + | | start = |
* '''Day 1:''' simultaneously start administration of doxepin in a normal dosage of 25 mg/day. | * '''Day 1:''' simultaneously start administration of doxepin in a normal dosage of 25 mg/day. | ||
* '''Day 8:''' stop administration of citalopram/escitalopram and continue administration of doxepin only. | * '''Day 8:''' stop administration of citalopram/escitalopram and continue administration of doxepin only. | ||
Revision as of 18:48, 4 May 2009
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Switch medication from citalopram to doxepin.[2] [3]
Stop citalopram - Day 0: gradually reduce dosage of citalopram/escitalopram to a maximum of 20 mg/ day resp. 10 mg/day, when this dosage is respectively > 20 mg/day and > 10 mg/day.
- Day 1: reduce dosage of citalopram/escitalopram to a maximum of 10 mg/ day resp. 5 mg/day.
Start doxepin- Day 1: simultaneously start administration of doxepin in a normal dosage of 25 mg/day.
- Day 8: stop administration of citalopram/escitalopram and continue administration of doxepin only.
More information- “Start low, go slow” for doxepin is not required, but caution is necessary.
- The same applies to escitalopram.
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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