Difference between revisions of "Doxepine-citalopram"

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| to = citalopram  
 
| to = citalopram  
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of doxepin to a maximum of 100 mg/day.
+
{{downDoxepin}}
* '''Day 1:''' reduce dosage of doxepin to 50 mg/day.
 
* '''Day 3:''' reduce dosage of doxepin to 25 mg/day.
 
* '''Day 8:''' stop administration of doxepin.
 
 
| start =  
 
| start =  
 
* '''Day 1:''' simultaneously start administration of citalopram in a normal dosage of 20 mg/day.
 
* '''Day 1:''' simultaneously start administration of citalopram in a normal dosage of 20 mg/day.
 
| info =  
 
| info =  
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
+
* {{theorSS}}
 
* Citalopram is a weak inhibitor of CYP2D6, which metabolizes doxepin.   
 
* Citalopram is a weak inhibitor of CYP2D6, which metabolizes doxepin.   
 
}}
 
}}

Revision as of 13:21, 2 November 2015

Doxepin
Type antidepressant
Group TCA
links
ATC-code N06AA12
Medscape Doxepin
PubChem 3158
PubMed Doxepin
Drugs.com doxepin
Kompas (Dutch) Doxepin
Wikipedia Doxepin
Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram

Switch medication from doxepin to citalopram.[2] [3]

Nietinrijdenbord.png Stop doxepin
  • Before day 1: gradually reduce dosage of doxepin to a maximum of 100 mg/day.
  • Day 1: reduce dosage of doxepin to 50 mg/day.
  • Day 3: reduce dosage of doxepin to 25 mg/day.
  • Day 8: stop administration of doxepin.
Eenrichtingbord.png Start citalopram
  • Day 1: simultaneously start administration of citalopram in a normal dosage of 20 mg/day.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  • Citalopram is a weak inhibitor of CYP2D6, which metabolizes doxepin.
  1. 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
  2. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  3. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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