Difference between revisions of "Fluoxetine-clomipramine"
From Psychiatrienet
(Created page with '{{Drugswitch | from = fluoxetine | to = clomipramine | stop = * Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day. * When a d...') |
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Caution is necessary for at least four weeks. | Caution is necessary for at least four weeks. | ||
* '''Day 1:''' start administration of clomipramine in a low dosage of 25 mg/day. | * '''Day 1:''' start administration of clomipramine in a low dosage of 25 mg/day. | ||
| − | * '''Day 8:''' increase dosage of clomipramine to 50 | + | * '''Day 8:''' increase dosage of clomipramine to 50 mg/day. |
| − | * '''Day | + | * '''Day 28:''' gradually increase dosage of clomipramine to 75 mg/day and more. |
| info = | | info = | ||
* Fluoxetine slows the metabolism of clomipramine via CYP2D6. | * Fluoxetine slows the metabolism of clomipramine via CYP2D6. | ||
| − | * Start low, go slow for clomipramine.}} | + | * Desmethylfluoxetine has a halflife of at least 1 week: it takes therefore 1 month for elemination. |
| + | * Start low, go slow for clomipramine. | ||
| + | }} | ||
Revision as of 08:02, 3 August 2009
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Switch medication from fluoxetine to clomipramine.[1] [2]
Stop fluoxetine - Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
- When a dosage of 20 mg/day is reached, stop administration.
Start clomipramineCaution is necessary for at least four weeks.
- Day 1: start administration of clomipramine in a low dosage of 25 mg/day.
- Day 8: increase dosage of clomipramine to 50 mg/day.
- Day 28: gradually increase dosage of clomipramine to 75 mg/day and more.
More information- Fluoxetine slows the metabolism of clomipramine via CYP2D6.
- Desmethylfluoxetine has a halflife of at least 1 week: it takes therefore 1 month for elemination.
- Start low, go slow for clomipramine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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