Difference between revisions of "Sertraline-tranylcypromine"
From Psychiatrienet
(Created page with '{{Drugswitch | from = sertraline | to = tranylcypromine | stop = * '''Before day 0:''' gradually reduce dosage of sertraline to a maximum of 25 mg/day, when this dosage is > 2...') |
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* '''Day 1-7:''' a wash-out period of one week is necessary. | * '''Day 1-7:''' a wash-out period of one week is necessary. | ||
| − | * '''Day 8:''' start tranylcypromine the next day in a normal dosage of 20 mg/day. | + | * '''Day 8:''' start tranylcypromine the next day in a normal dosage of 20 mg/day for one week. |
| + | * '''Day 15:''' after this week the dosage of tranylcypromine can be increased if necessary. | ||
| info = | | info = | ||
* A switch from sertraline to tranylcypromine is not obvious, given the necessary prolonged wash-out period in this case. | * A switch from sertraline to tranylcypromine is not obvious, given the necessary prolonged wash-out period in this case. | ||
* Occurrence of serotonin syndrome is reported when a wash-out period (of one week) is not considered.}} | * Occurrence of serotonin syndrome is reported when a wash-out period (of one week) is not considered.}} | ||
Revision as of 10:48, 6 May 2009
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Switch medication from sertraline to tranylcypromine.[1] [2]
Stop sertraline - Before day 0: gradually reduce dosage of sertraline to a maximum of 25 mg/day, when this dosage is > 25 mg/day.
- Day 1: stop administration of sertraline.
Start tranylcypromine- Day 1-7: a wash-out period of one week is necessary.
- Day 8: start tranylcypromine the next day in a normal dosage of 20 mg/day for one week.
- Day 15: after this week the dosage of tranylcypromine can be increased if necessary.
More information- A switch from sertraline to tranylcypromine is not obvious, given the necessary prolonged wash-out period in this case.
- Occurrence of serotonin syndrome is reported when a wash-out period (of one week) is not considered.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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