Difference between revisions of "Moclobemide-maprotiline"

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(Created page with '{{Drugswitch | from = moclobemide | to = maprotiline | stop = Administration of moclobemide can be stopped abruptly. | start = * '''Day 1-2:''' a wash-out period of two days...')
 
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| to = maprotiline  
 
| to = maprotiline  
 
| stop =  
 
| stop =  
Administration of moclobemide can be stopped abruptly.
+
* '''Before day 0:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
 +
* '''Day 1:''' reduce the dosage of moclobemide to 150 mg/day.
 +
* '''Day 8:''' stop administration of moclobemide.
 
| start =  
 
| start =  
* '''Day 1-2:''' a wash-out period of two days is necessary.  
+
* '''Day 8-9:''' a wash-out period of two days is necessary.  
* '''Day 3:''' start maprotiline after this period in a normal dosage of 25-75 mg/day.
+
* '''Day 10:''' start maprotiline after this period in a normal dosage of 25-75 mg/day.
 
* “Start low, go slow” is not required, but caution is necessary.}}
 
* “Start low, go slow” is not required, but caution is necessary.}}

Revision as of 15:13, 7 May 2009

Moclobemide
Type Antidepressant
Group MAO-I
links
Medscape Moclobemide
PubChem 4235
PubMed Moclobemide
Kompas (Dutch) Moclobemide
Wikipedia Moclobemide
Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline

Switch medication from moclobemide to maprotiline.[1] [2]

Nietinrijdenbord.png Stop moclobemide
  • Before day 0: gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
  • Day 1: reduce the dosage of moclobemide to 150 mg/day.
  • Day 8: stop administration of moclobemide.
Eenrichtingbord.png Start maprotiline
  • Day 8-9: a wash-out period of two days is necessary.
  • Day 10: start maprotiline after this period in a normal dosage of 25-75 mg/day.
  • “Start low, go slow” is not required, but caution is necessary.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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