Difference between revisions of "Citalopram-vortioxetine"
From Psychiatrienet
| Line 2: | Line 2: | ||
| from = citalopram | | from = citalopram | ||
| to = vortioxetine | | to = vortioxetine | ||
| − | | stop = | + | | stop = |
| + | * '''Before day 1:'''Gradually reduce dosage of citalopram to a maximum of 20 mg/day, when this dosage is > 20 mg/day. | ||
| + | * '''Day 1:''' When a dosage of 20 mg/day is reached, stop administration. | ||
| start = | | start = | ||
* A wash-out period is not necessary. | * A wash-out period is not necessary. | ||
| − | * Start administration of vortioxetine the next day in a dosage of 10 mg/day. | + | * '''Day 1:'''Start administration of vortioxetine the next day in a dosage of 10 mg/day. |
| info = | | info = | ||
* {{theorSS}}<ref>[[European Medicines Agency]] | SmPC Brintellix 5 mg. </ref> | * {{theorSS}}<ref>[[European Medicines Agency]] | SmPC Brintellix 5 mg. </ref> | ||
}} | }} | ||
Revision as of 14:14, 4 March 2015
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Switch medication from citalopram to vortioxetine.[1] [2]
Stop citalopram - Before day 1:Gradually reduce dosage of citalopram to a maximum of 20 mg/day, when this dosage is > 20 mg/day.
- Day 1: When a dosage of 20 mg/day is reached, stop administration.
Start vortioxetine- A wash-out period is not necessary.
- Day 1:Start administration of vortioxetine the next day in a dosage of 10 mg/day.
More information- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.[3]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ European Medicines Agency | SmPC Brintellix 5 mg.
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