Difference between revisions of "Fluoxetine-vortioxetine"
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* A wash-out period is not necessary, but care is needed. | * A wash-out period is not necessary, but care is needed. | ||
| − | * '''Day 1:''' start administration of vortioxetine | + | * '''Day 1:''' start administration of vortioxetine in a dosage of 10 mg/day. |
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* Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. | * Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. | ||
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | ||
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Revision as of 15:21, 4 March 2015
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Switch medication from fluoxetine to vortioxetine.[1] [2]
Stop fluoxetine - Before day 1: gradually reduce dosage of escitalopram to a maximum of 10 mg/day, when this dosage is > 10 mg/day.
- Day 1: when a dosage of 10 mg/day is reached, stop administration
Start vortioxetine- A wash-out period is not necessary, but care is needed.
- Day 1: start administration of vortioxetine in a dosage of 10 mg/day.
More information- Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine.
- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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