Difference between revisions of "Duloxetine-vortioxetine"
From Psychiatrienet
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* '''Before day 1:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/day, when this dosage is > 60 mg/day. | * '''Before day 1:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/day, when this dosage is > 60 mg/day. | ||
| − | * '''Day 1 | + | * '''Day 1:''' reduce dosage of duloxetine from 60 mg/day to 30 mg/day. |
| − | * '''Day 8 | + | * '''Day 8:''' stop duloxetine. |
| − | + | ||
| start = | | start = | ||
| − | * A wash-out period is | + | * A wash-out period of 3 days is advisable. |
| − | * '''Day | + | * '''Day 11:''' Start administration of vortioxetine in a dosage of 10 mg/day. |
| info = | | info = | ||
| − | * Duloxetine is | + | * Duloxetine is an inhibitor of CYP2D6, which metabolizes vortioxetine. |
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | ||
| − | + | ||
}} | }} | ||
Revision as of 14:13, 12 March 2015
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Switch medication from duloxetine to vortioxetine.[1] [2]
Stop duloxetine - Before day 1: gradually reduce dosage of duloxetine to a maximum of 60 mg/day, when this dosage is > 60 mg/day.
- Day 1: reduce dosage of duloxetine from 60 mg/day to 30 mg/day.
- Day 8: stop duloxetine.
Start vortioxetine- A wash-out period of 3 days is advisable.
- Day 11: Start administration of vortioxetine in a dosage of 10 mg/day.
More information- Duloxetine is an inhibitor of CYP2D6, which metabolizes vortioxetine.
- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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