Difference between revisions of "Vortioxetine-fluoxetine"
From Psychiatrienet
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* A wash-out period of 2 weeks is necessary, because of CYP2D6-inhibition. | * A wash-out period of 2 weeks is necessary, because of CYP2D6-inhibition. | ||
| + | * '''Day 22:''' start administration of fluoxetine in a normal dosage of 20 mg/day. | ||
{{Day22NoBloodlevelvortioxetine}} | {{Day22NoBloodlevelvortioxetine}} | ||
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| info = | | info = | ||
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | ||
* Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. }} | * Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. }} | ||
Revision as of 13:27, 12 March 2015
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Switch medication from vortioxetine to fluoxetine.[1] [2]
Stop vortioxetine - Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 8: stop administration of vortioxetine.
Start fluoxetine- A wash-out period of 2 weeks is necessary, because of CYP2D6-inhibition.
- Day 22: start administration of fluoxetine in a normal dosage of 20 mg/day.
- Day 22: bloodlevel vortioxetine is now zero, so you can increase faster.
More information- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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