Difference between revisions of "Duloxetine-vortioxetine"
From Psychiatrienet
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* Duloxetine is an inhibitor of CYP2D6, which metabolizes vortioxetine. | * Duloxetine is an inhibitor of CYP2D6, which metabolizes vortioxetine. | ||
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | ||
| − | + | {{review}} | |
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Revision as of 14:51, 2 November 2015
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Switch medication from duloxetine to vortioxetine.[1] [2]
Stop duloxetine - Before day 1: gradually reduce dosage of duloxetine to a maximum of 60 mg/day, when this dosage is > 60 mg/day.
- Day 1: reduce dosage of duloxetine from 60 mg/day to 30 mg/day.
- Day 8: stop duloxetine.
Start vortioxetine- A wash-out period of 3 days is advisable.
- Day 11: Start administration of vortioxetine in a dosage of 10 mg/day.
More information- Duloxetine is an inhibitor of CYP2D6, which metabolizes vortioxetine.
- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- This switch is currently being reviewed.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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