Difference between revisions of "Sertraline-tranylcypromine"
From Psychiatrienet
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* '''Before day 1:''' | * '''Before day 1:''' | ||
* '''Day 1:''' reduce dosage of sertraline to 100 mg/day. | * '''Day 1:''' reduce dosage of sertraline to 100 mg/day. | ||
| − | * ''' Day 5: ''' reduce dosage of sertraline to 50 | + | * ''' Day 5: ''' reduce dosage of sertraline to 50 mg/day. |
* ''' Day 9: ''' reduce dosage of sertraline to 25 mg/day. | * ''' Day 9: ''' reduce dosage of sertraline to 25 mg/day. | ||
* ''' Day 14:''' stop sertraline. | * ''' Day 14:''' stop sertraline. | ||
Revision as of 08:50, 21 October 2015
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Switch medication from sertraline to tranylcypromine.[1] [2]
Stop sertraline - Before day 1:
- Day 1: reduce dosage of sertraline to 100 mg/day.
- Day 5: reduce dosage of sertraline to 50 mg/day.
- Day 9: reduce dosage of sertraline to 25 mg/day.
- Day 14: stop sertraline.
Start tranylcypromine- Day 14-28: a wash-out period of 2 weeks is necessary.
- Day 29: start tranylcypromine the next day in a low dosage of 20 mg/day for one week.
- Day 36: after this week the dosage of tranylcypromine can be increased gradually.
Cave- Occurrence of the serotonin syndrome is possible without wash-out period.
- The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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