Difference between revisions of "Sertraline-mirtazapine"
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| − | * '''Day | + | * '''Day 9:''' start mirtazapine in a normal dosage of 15 mg/day for one week. |
| − | * '''Day | + | * '''Day 16:''' if necessary gradually increase the dosage of mirtazapine to target dose. |
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Revision as of 14:17, 21 October 2015
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Switch medication from sertraline to mirtazapine.[1] [2]
Stop sertraline - Before day 1: Gradually reduce dosage of sertraline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
- Day 1: Reduce dosage of sertraline to a dosage of 25 mg/ day
- Day 8: Stop administration of sertraline
Start mirtazapine- Day 9: start mirtazapine in a normal dosage of 15 mg/day for one week.
- Day 16: if necessary gradually increase the dosage of mirtazapine to target dose.
More information- The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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