Difference between revisions of "Paroxetine-fluoxetine"

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* No wash-out period is needed.
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* '''Day 1:''' start fluoxetine in normal dosage of 20 mg/day.
* '''Day 9:''' start fluoxetine in normal dosage of 20 mg/day.
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* ''' After 2 weeks:''' If necessary, gradually increase dosage of fluoxetine.
 
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* {{theorSS}}
 
 
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Revision as of 14:07, 8 March 2024

paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine
Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine

Switch medication from paroxetine to fluoxetine.[1] [2]

Nietinrijdenbord.png Stop paroxetine
  • Before day 1: gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day.
  • Day 1: reduce dosage of paroxetine to a maximum of 10 mg/day.
  • Day 8: stop administration of paroxetine.
Eenrichtingbord.png Start fluoxetine
  • Day 1: start fluoxetine in normal dosage of 20 mg/day.
  • After 2 weeks: If necessary, gradually increase dosage of fluoxetine.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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