Difference between revisions of "Imipramine-duloxetine"
From Psychiatrienet
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* '''Day 3:''' reduce dosage of imipramine to 25 mg/day. | * '''Day 3:''' reduce dosage of imipramine to 25 mg/day. | ||
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| − | * '''Day | + | * '''Day 4:''' simultaneously start administration of duloxetine in a normal dosage of 60 mg/day. |
* '''Day 8:''' stop administration of imipramine and continue administration of duloxetine. | * '''Day 8:''' stop administration of imipramine and continue administration of duloxetine. | ||
| info = | | info = | ||
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | ||
* Duloxetine is a inhibitor of CYP2D6, which metabolizes imipramine.}} | * Duloxetine is a inhibitor of CYP2D6, which metabolizes imipramine.}} | ||
Revision as of 19:55, 30 July 2009
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Switch medication from imipramine to duloxetine.[1] [2]
Stop imipramine - Before day 0: gradually reduce dosage of imipramine to a maximum of 75 mg/day.
- Day 1: reduce dosage of imipramine to 50 mg/day.
- Day 3: reduce dosage of imipramine to 25 mg/day.
Start duloxetine- Day 4: simultaneously start administration of duloxetine in a normal dosage of 60 mg/day.
- Day 8: stop administration of imipramine and continue administration of duloxetine.
More information- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- Duloxetine is a inhibitor of CYP2D6, which metabolizes imipramine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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