Difference between revisions of "Amitriptyline-dosulepine"
From Psychiatrienet
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| from = amitriptyline | | from = amitriptyline | ||
| to = dosulepine | | to = dosulepine | ||
| − | | stop = | + | | stop = |
| − | + | {{stopAmitriptyline}} | |
| − | | start = * No wash-out period is needed. | + | | start = |
| − | * Start administration of dosulepine | + | * No wash-out period is needed. |
| + | *''' Day 9: ''' Start administration of dosulepine in a normal dosage of 50-75 mg/day. | ||
| info = | | info = | ||
* {{TCAantichol}} | * {{TCAantichol}} | ||
| − | |||
}} | }} | ||
Revision as of 12:55, 2 November 2015
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Switch medication from amitriptyline to dosulepine.[1] [2]
Stop amitriptyline - Before day 1: gradually reduce dosage of amitriptyline to a maximum of 50-100 mg/ day, when this dosage is > 100 mg/day.
- Day 1-3: reduce dosage of amitriptyline to 50 mg/day.
- Day 4-7: reduce dosage of amitriptyline to 25 mg/day.
- Day 8: stop administration of amitriptyline.
Start dosulepine- No wash-out period is needed.
- Day 9: Start administration of dosulepine in a normal dosage of 50-75 mg/day.
More information- Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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