Difference between revisions of "Amitriptyline-fluoxetine"
From Psychiatrienet
| Line 3: | Line 3: | ||
| to = fluoxetine | | to = fluoxetine | ||
| stop = | | stop = | ||
| − | {{ | + | {{stopAmitriptyline}} |
| start = | | start = | ||
| − | * '''Day | + | * '''Day 9:''' start administration of fluoxetine in a normal dosage of 20 mg/day. |
| − | * '''Day | + | * '''Day 16:''' if necessary, increase dosage of fluoxetine. |
| info = | | info = | ||
*{{theorSS}} | *{{theorSS}} | ||
* Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong) and CYP3A4 (moderate), which metabolize amitriptyline. | * Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong) and CYP3A4 (moderate), which metabolize amitriptyline. | ||
}} | }} | ||
Revision as of 12:53, 2 November 2015
| ||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||
Switch medication from amitriptyline to fluoxetine.[1] [2]
Stop amitriptyline - Before day 1: gradually reduce dosage of amitriptyline to a maximum of 50-100 mg/ day, when this dosage is > 100 mg/day.
- Day 1-3: reduce dosage of amitriptyline to 50 mg/day.
- Day 4-7: reduce dosage of amitriptyline to 25 mg/day.
- Day 8: stop administration of amitriptyline.
Start fluoxetine- Day 9: start administration of fluoxetine in a normal dosage of 20 mg/day.
- Day 16: if necessary, increase dosage of fluoxetine.
More information- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong) and CYP3A4 (moderate), which metabolize amitriptyline.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
