Difference between revisions of "Doxepine-nortriptyline"
From Psychiatrienet
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* No wash-out period is needed. | * No wash-out period is needed. | ||
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* {{TCAantichol}} | * {{TCAantichol}} | ||
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Revision as of 12:47, 16 June 2016
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Switch medication from doxepin to nortriptyline.[2] [3]
Stop doxepin - Day 1: Decrease with about 25% of the original dose per 3 days.
Start nortriptyline- No wash-out period is needed.
- Day 1: Increase with about 25% of target dose per 3 days.
More information- Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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