Difference between revisions of "Vortioxetine-mirtazapine"
From Psychiatrienet
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| to = mirtazapine | | to = mirtazapine | ||
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| − | {{stopVortioxetine}} | + | {{stopVortioxetine}}<ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetine}}</ref> |
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* '''Day 9:''' start mirtazapine in a normal dosage of 15-30 mg/day. | * '''Day 9:''' start mirtazapine in a normal dosage of 15-30 mg/day. | ||
| info = | | info = | ||
* Mirtazapine is a very weak inhibitor of CYP2D6. | * Mirtazapine is a very weak inhibitor of CYP2D6. | ||
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}} | }} | ||
Revision as of 15:09, 4 November 2015
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Switch medication from vortioxetine to mirtazapine.[1] [2]
Stop vortioxetine - Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 8: stop administration of vortioxetine.[3] [4]
Start mirtazapine- Day 9: start mirtazapine in a normal dosage of 15-30 mg/day.
More information- Mirtazapine is a very weak inhibitor of CYP2D6.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54
- ↑ KNMP; Informatorium Medicamentorum 2023; Monografie "vortioxetine" (Dutch)
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