Difference between revisions of "Duloxetine-amitriptyline"

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| to = amitriptyline  
 
| to = amitriptyline  
 
| stop =  
 
| stop =  
{{stopDuloxetine}}
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{{TCAdecrease25p3d}}
 
| start =  
 
| start =  
* '''Day 9-15:''' wash-out period of one week is necessary.
+
{{TCAincrease25p3d}}
* '''Day 16:''' start administration of amitriptyline in a low dosage of 25 mg/day.
+
| info =
| info =  
+
{{TCAplasmalevelmonitoring}}
* Start low, go slow for amitriptyline!
 
* Duloxetine is a moderate inhibitor of CYP2D6, which metabolizes amitriptyline. }}
 

Revision as of 12:48, 30 June 2023

{{Drugswitch | from = duloxetine | to = amitriptyline | stop =

  • Day 1: Decrease with about 25% of the original dose per 3 days.

| start =

  • Day 1: Increase with about 25% of target dose per 3 days.

| info =

  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[1]
  • (dutch) monografie.org tricyclische-antidepressiva