Difference between revisions of "Clomipramine-mianserine"
From Psychiatrienet
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* '''Day 1:''' simultaneously start administration of mianserine in a low dosage of 30 mg/day. | * '''Day 1:''' simultaneously start administration of mianserine in a low dosage of 30 mg/day. | ||
* '''Day 8:''' stop administration of clomipramine and continue administration of mianserine. | * '''Day 8:''' stop administration of clomipramine and continue administration of mianserine. | ||
| − | * If necessary, increase dosage of mianserine. }} | + | * If necessary, increase dosage of mianserine. |
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Revision as of 12:20, 28 July 2009
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Switch medication from clomipramine to mianserine.[1] [2]
Stop clomipramine - Before day 0: gradually reduce dosage of clomipramine to a maximum of 50 mg/day.
- Day 1: reduce dosage of clomipramine to 25 mg/day.
- Day 3: reduce dosage of clomipramine to 10 mg/day.
Start mianserine- Day 1: simultaneously start administration of mianserine in a low dosage of 30 mg/day.
- Day 8: stop administration of clomipramine and continue administration of mianserine.
- If necessary, increase dosage of mianserine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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