Difference between revisions of "Tranylcypromine-agomelatine"
From Psychiatrienet
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| − | {{Inc25p3do50pw}}<ref name="informatorium">{{KNMP|tranylcypromine}}</ref><ref>Dr. M.J.Blom et al. Gebruik van klassieke MAO-remmers</ref> | + | {{Inc25p3do50pw}}<ref name="informatorium">{{KNMP|tranylcypromine}}</ref> <ref>Dr. M.J.Blom et al. Gebruik van klassieke MAO-remmers</ref> |
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* Tranylcypromine has to be phased out to avoid withdrawal symptoms. | * Tranylcypromine has to be phased out to avoid withdrawal symptoms. | ||
Revision as of 14:33, 30 June 2023
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Switch medication from tranylcypromine to agomelatine.[1] [2]
Stop tranylcypromine - Day 1: decrease the original dose with about 25% every 3 days.
- Day 9: stop administration of tranylcypromine.
Start agomelatine- Day 15: Start and increase the dose with about 25% of the target dose every 3 days or 50% per week.[3] [4]
More information- Tranylcypromine has to be phased out to avoid withdrawal symptoms.
- After the last dose of tranylcypromine it takes about 14 days to restore the activity of the MAO enzymes[3]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ 3.0 3.1 KNMP; Informatorium Medicamentorum 2023; Monografie "tranylcypromine" (Dutch)
- ↑ Dr. M.J.Blom et al. Gebruik van klassieke MAO-remmers
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