Changes

| to = citalopram nortriptyline

* Gradually '''Day 0:''' gradually reduce dosage of paroxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day. * When '''Day 1:''' reduce dosage of paroxetine to a maximum of 10 mg/day. * '''Day 8:''' reduce dosage of 20 paroxetine to 5 mg/day is reached, stop administration.

* No wash-out period Caution is needednecessary. * Start citalopram/escitalopram the next day '''Day 8:''' simultaneously start administration of nortriptyline in normal a low dosage of 20 25 mg/day, resp. 10 * '''Day 15:''' stop administration of paroxetine and only continue administration of noritriptyline in a dosage of 50 mg/day.* "Start low, go slow" is not required, but caution is necessary!| info = * Paroxetine slows the metabolism of nortriptyline via CYP2D6.}}