Difference between revisions of "Vortioxetine-fluoxetine"

Revision as of 14:10, 20 February 2025

{{Drugswitch | from = vortioxetine | to = fluoxetine | stop =

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Day 6 and after: At approximately 50-25% of the original vortioxetine dose start fluoxetine at 100% of the target dose.
After 3 weeks: If necessary, gradually increase dosage of fluoxetine.

| info =

Safe target dose fluoxetine = 20 mg
Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong), which metabolizes vortioxetine

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 | to = fluoxetine
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-{{stopVortioxetine}}
+{{TCAdecrease25p3d}}
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-* A wash-out period of 2 weeks is necessary, because of CYP2D6-inhibition.
+* '''Day 6 and after''': At approximately 50-25% of the original vortioxetine dose start fluoxetine at 100% of the target dose.
-* '''Day 23:''' start administration of fluoxetine in a normal dosage of 20 mg/day.
+* ''' After 3 weeks:''' If necessary, gradually increase dosage of fluoxetine.
 | info =
-* {{theorSS}}
+* Safe target dose fluoxetine = 20 mg
-* Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine.
+* Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong), which metabolizes vortioxetine
-<ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetine}}</ref> }}