Difference between revisions of "Doxepine-hypericum"
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(Created page with '{{ Drugswitch | from = doxepin | to = hypericum | stop = * '''Before day 0:''' gradually reduce dosage of doxepin to a maximum of 100 mg/day, when this dosage is > 100 mg/day...') |
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* '''Day 15:''' stop administration of doxepin. | * '''Day 15:''' stop administration of doxepin. | ||
| start = | | start = | ||
| − | * '''Day | + | * '''Day 15-22:''' a wash-out period of one week is necessary. |
| − | * '''Day | + | * '''Day 23:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day). |
| info = | | info = | ||
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | ||
* Hypericum slows the metabolism of doxepin via CYP3A4. }} | * Hypericum slows the metabolism of doxepin via CYP3A4. }} | ||
Revision as of 12:24, 7 May 2009
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Switch medication from doxepin to hypericum.[2] [3]
Stop doxepin - Before day 0: gradually reduce dosage of doxepin to a maximum of 100 mg/day, when this dosage is > 100 mg/day.
- Day 1: reduce dosage of doxepin to 50 mg/day.
- Day 8: reduce dosage of doxepin to 25 mg/day.
- Day 15: stop administration of doxepin.
Start hypericum- Day 15-22: a wash-out period of one week is necessary.
- Day 23: start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).
More information- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- Hypericum slows the metabolism of doxepin via CYP3A4.
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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